Meanwhile, no difference in the liver histopathology and hepatic lipid accumulation in TNF-α-induced hepatic insulin resistance mice with FGF-1 treatment (Figures S3C, D); however, FGF-1 ameliorated TNF-α-induced insulin resistance, as assessed by decreased insulin levels and reduced insulin resistance index HOMA-IR (Figures 4B, C). The gene discussed is FGF1; the disease is Insulin resistance.