In this review, we systemically discussed the potential effects and mechanisms of triptolide in the treatment of different inflammatory diseases including MN, lupus nephritis, kidney transplantation, IBD, asthma, ALI, PAH, etc. Firstly, triptolide could reduce the production of inflammatory mediators such as TNF-α, IL-6, IL-17. The gene discussed is TNF; the disease is inflammatory bowel disease.