Li et al. (2010) found that triptolide ameliorates colitis by suppressing the IL-6/signal transducer and activator of transcription 3 (STAT3) signaling pathway and downregulating IL-17. Zhang et al. (2014) found that 0.6 mg/kg/day triptolide administration ameliorates intestinal injury by inhibiting the expression of secondary lymphoid tissue chemokine chemokine (C-C motif) ligand 21 (CCL21), which has chemotactic effects on T cells, B cells, NK cells, and DCs. The gene discussed is STAT3; the disease is colitis.