CYP11A1 and neuropathic pain: In this regard, we investigated whether: (1) sciatic nerve injury increases the immunoreactivity of P450scc in the spinal cord; (2) i.t. administration of the P450scc inhibitor, aminoglutethimide (AMG), suppresses the CCI-induced mechanical allodynia and thermal hyperalgesia in a mouse model of neuropathic pain; (3) i.t. administration of AMG inhibits the CCI-induced increased expression and/or activation of Srr and D-serine production in the spinal cord; and (4) exogenous D-serine restores the CCI-induced development of the neuropathic pain that was suppressed by the inhibition of P450scc.