Given that TGF-β1 is a pivotal cytokine in tissue fibrosis, Irifuku et al. (2016) examined the expression of G9a and its role in a murine model of UUO-induced renal fibrosis by administration of G9a small interfering RNA and BIX01294, a specific inhibitor of G9a. This evidence concerns the gene EHMT2 and renal fibrosis.