SUV39H1 and liver dysplastic nodule: Interestingly, genetic or pharmacological inhibition of phosphoinositide 3-kinase (PI3K) reduced high glucose-induced downregulation of SUV39H1 in mesangial cells, while genetic overexpression of SUV39H1 or pharmacological increase of SUV39H1 was protective against the progression of DN (Lin et al., 2016).