TGFB1 and renal fibrosis: Further studies showed that inhibition of SET7/9 with sinefungin, a selective inhibitor of SET7/9 or siRNA attenuated renal fibrosis, as indicated by decreased expression of mesenchymal markers and ECM proteins in kidneys of UUO mice; sinefungin can also inhibit expression of TGF-β1-induced α-smooth muscle actin expression in cultured renal epithelial cells and renal interstitial fibroblasts (Sasaki et al., 2016).