IGHE and allergic asthma: Because IgE and the high affinity receptor for IgE (FcεRI) play a central role in atopic asthma (Varricchi et al., 2018d; Borriello et al., 2019; Varricchi et al., 2019), a mAb anti-IgE (omalizumab) is indicated for the treatment of patients (aged ≥ 12 years) with moderate-to-severe uncontrolled allergic asthma (Samitas et al., 2015; Hew et al., 2016).