IGHE and asthma: Asthma can be classified according to two major endotypes: “T2-high” asthma is characterized by increased levels of type 2 inflammation mainly mediated by mast cells, eosinophils, basophils, T-helper 2 cells, group 2 innate lymphoid cells (ILC2s), and immunoglobulin E (IgE)-producing B cells (Fahy, 2015).