POSTN and asthma: In two replicate studies (LUTE and VERSE) in patients with moderate-to-severe uncontrolled asthma, lebrikizumab (37.5, 125 or 250 mg s.c. every 4 weeks) reduced asthma exacerbation rate by 60% compared to placebo in periostin-high patients and by 5% in periostin-low patients (Hanania et al., 2015).