A randomized, double-blind, placebo controlled study examined the effects of another anti-IL-13 mAb, lebrikizumab (250 mg s.c. once monthly for 6 months), on change in prebronchodilator FEV1 from baseline to week 12 in 219 adults with uncontrolled asthma (Corren et al., 2011). The gene discussed is IL13; the disease is asthma.