NOS2 and neurodegenerative disease: 5,3′-Dihydroxy-3,7,4-trimethoxyflavone (DTMF) from Siegesbeckia pubescens (Makino) Makino (Compositae) can reduce the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) and promote HO-1 expression, HO activity, Nrf2 nuclear translocation and antioxidant response element (ARE)-luciferase activity, suggesting that it may represent an effective treatment for neurodegenerative diseases caused by oxidative stress (Lee et al., 2016).