Gao et al. (2014) administered geniposide [50 M, 10 L, isolated from the fruit of G. jasminoides J.Ellis (Rubiaceae)] through oral gavage or unilateral injections into the ventricle of AD model mice treated with STZ and found that geniposide could reduce the hyperactivity of GSK3β induced by STZ by western blotting analysis. Meanwhile, geniposide improved the spatial learning of rats. According to this new evidence, the active monomer of geniposide can be used as a new therapeutic agent for AD (Gao et al., 2014). The gene discussed is GSK3B; the disease is Alzheimer disease.