As shown in the study by Li et al. (2016a), TIIA could reduce the accumulation of the 1–42 CTF of the β-amyloid protein in an AD model, promote depolarization-induced BDNF synthesis without affecting total BDNF levels, and relieving the memory impairment in the AD mice, which further confirmed the protective effect of BDNF on cholinergic neurons. This evidence concerns the gene BDNF and Alzheimer disease.