PTGS2 and breast cancer: It has been reported that administration of genistein in combination with three polyunsaturated fatty acids, namely docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid, increased PPARγ expression in MDA-MB-231 human breast cancer cells, and decreased expression of inflammatory molecules cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) thereby reverting invasiveness in breast cancer cells (Horia and Watkins, 2007).