MMP2 and prostate carcinoma: In a study monitoring the short-term versus long-term effect of genistein treatment in prostate cancer, short term treatment of PC3-M cells (metastatic prostate cancer cells) in vitro over a period of 8 weeks decreased MMP-2 expression whereas long-term treatment up to 2 months increased MMP-2 levels, emphasizing the fact that early phase chemoprevention trails need to be closely monitored for optimal dose administration duration for maximum efficacy (Zhang et al., 2019).