In individuals with mild cognitive impairment, as well as in PDGFRβ+/– mice, soluble PDGFRβ (sPDGFRβ) increases in the cerebrospinal fluid (CSF) following pericyte loss (Montagne et al., 2015), suggesting sPDGFRβ may serve as a biomarker for pericyte death. This evidence concerns the gene PDGFRB and Cognitive impairment.