To determine whether bpV[pic]-induced neuroprotection in ICH is mediated through E2F1 and β-catenin signaling, we examined the expression of E2F1 and β-catenin in primary cortical neurons and the PTEN-deficient human glioblastoma U251 cells after treatment with bpV[pic] or PTEN siRNA. Here, E2F1 is linked to glioblastoma.