Additionally, non-native formations of wild-type SOD1 have been detected in small granular SOD1-immunoreactive inclusions in the motor neurons of sALS patients without pathogenic SOD1 variants (Forsberg et al., 2010) and in patients carrying the C9ORF72 repeat expansion and pathogenic variants in other ALS-associated genes (Forsberg et al., 2019). Here, SOD1 is linked to amyotrophic lateral sclerosis.