SOD1 rodent lines generally develop adult-onset motor neuron disease, reminiscent of the human disease with hallmarks of human disease such as SOD1 aggregation, excitotoxic cell death of neurons, neuroinflammatory reactions and altered oligodendrocyte biology replicated in SOD1 mouse models (Philips and Rothstein, 2015). This evidence concerns the gene SOD1 and motor neuron disorder.