SETX and amyotrophic lateral sclerosis: Variations in the genes of other ALS-linked RNA-binding proteins, including TAF15, SETX, and EWSR1 have also been linked to impaired DNA damage repair, further implicating the breakdown of this process in ALS pathogenesis (Paronetto et al., 2011; Skourti-Stathaki et al., 2011; Izhar et al., 2015).