In all three disease categories, the autosomal dominant diseases can be caused by gene duplications (Singleton et al., 2003; Rovelet-Lecrux et al., 2006, 2010) or by mutations which make protein deposition more likely either by changing the cleavage profile of Aβ so that a less soluble form is released (Scheuner et al., 1996) or by altering the splicing pattern of the MAPT gene so that more of the four repeat isoform of tau is produced (Hutton et al., 1998). Here, MAPT is linked to autosomal dominant disease.