Aggregates of cytoplasmic FUS induce cytotoxicity (Fushimi et al., 2011; Ju et al., 2011), mitochondrial dysfunction (Deng et al., 2015, 2018; Chen et al., 2016; Stoica et al., 2016), and impaired stress granule formation (Bentmann et al., 2012; Baron et al., 2013), which contributed to the pathogenesis of ALS. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.