However, the downregulated genes were not enriched in any KEGG pathways, while the upregulated genes were enriched in human papillomavirus infection, PI3K-Akt signaling pathway, ECM-receptor interaction, focal adhesion, protein digestion and absorption, and relaxin signaling pathway (Fig. 5a, FDR < 0.05). This evidence concerns the gene AKT1 and human papilloma virus infection.