Moreover, KLK6 has been reported to regulate epithelial-to-mesenchymal transition (EMT) and serve as prognostic biomarker for head and neck squamous cell carcinoma patients [27], which also indicated that the poor prognosis in MIBC samples with high expression of KLK6 might be associated with the dysfunction of EMT. The gene discussed is KLK6; the disease is head and neck squamous cell carcinoma.