NDUFAF8 and Leigh syndrome: The application of emerging “omics” tools—including but not limited to genomics, proteomics, and transcriptomics—to cohorts of clinically characterized individuals who lack a genetic diagnosis continues to identify novel candidate genes for Leigh syndrome, including TIMMDC1 (MIM: 615534), which was found through the use of transcriptomics,11 and NDUFAF8 (MIM: 618461), which was found through mass spectrometry-based proteomic analyses.12