The same PDE3A locus was recently reported to be associated at genome-wide significance with ischemic stroke in MEGASTROKE (lead SNP, rs7304841; odds ratio, 1.05 [95% CI, 1.03–1.07]; P=4.9×10−8).2 Effects were similar across ischemic stroke subtypes: cardioembolic stroke (odds ratio, 1.04 [95% CI, 1.00–1.08]), large artery stroke (odds ratio, 1.05 [95% CI, 1.00–1.10]), and small vessel stroke (odds ratio, 1.05 [95% CI, 1.01–1.08]). This evidence concerns the gene PDE3A and cardioembolic stroke.