Tumor PD‐L1 expression and/or serum PD‐L1 levels have been associated with inflammatory biomarkers, such as high white blood cell count,7 CRP levels,5 and IL‐6 expression in various types of tumors.12 To the best of our knowledge, correlations between serum PD‐L1 levels and these inflammatory biomarkers in patients with esophageal cancer have not been documented so far. This evidence concerns the gene CRP and esophageal cancer.