Consistent with this hypothesis is the observation of increased expression of VEGFA, cytokines, and MMPs in the synovium of early PsA patients compared to RA patients and the associated vascular morphology [7–9, 27] in addition to other growth factors such as Ang2, PIGF, and SDF-1 [10, 22]. The gene discussed is VEGFA; the disease is rheumatoid arthritis.