LRRK2 and Parkinson disease: Given the range of processes linked to LRRK2 it is perhaps unsurprising that LRRK2 has been implicated in ER stress responses, first indirectly, via the localisation of LRRK2 to the ER of intact dopaminergic neurons in healthy and PD brain tissue [191], and also directly, as part of a possible protective mechanism [192].