In order to investigate whether TRAIL resistance in esophageal cancer is also due to the deficiency of DRs, we firstly investigated the expression of DR4 and DR5 in 50 cases of ESCC specimens and 33 cases of adjacent tissues of tumor (tissues from the edge of the tumor tissue 5 cm) by immunohistochemistry. This evidence concerns the gene TNFRSF10A and esophageal cancer.