IGFBP3 and liver disorder: We also found a significant alteration (p < 0.004) of the mean IGF-1 level with the severity of liver disease, being the lowest in Child-Pugh C. Colakoglu et al [40] found IGF-1 and Insulin-like growth factor-binding protein 3 levels were significantly lower in 42 cirrhotic patients compared to non-cirrhotic ones.