The P values of all five features were less than 0.05 in the univariate analysis, whereas, in the multivariate analysis, clinical stage (P = 2.50E-08), histologic grade (P = 0.00378), and POLE (P = 0.00194) mutational status were shown to be independent prognostic factors in endometrial cancer patients (Table 2). Here, POLE is linked to endometrial cancer.