The top 10 mutated genes in endometrial cancer were: PTEN (57%), PIK3CA (48%), TTN (44%), ARID1A (43%), TP53 (36%), MUC16 (30%), PIK3R1 (30%), KMT2D (27%), CTCF (24%), and CSMD3 (24%). This evidence concerns the gene PIK3R1 and endometrial cancer.