The same authors reported that co-expression of CCR5 with CD4 and CXCR4 in the PM of HEK 293T cells and CD4+ CXCR4+ T cells was able to disrupt binding, entry and infection by X4-tropic HIV through the formation of CD4-CCR5-CXCR4 hetero-trimers that altered the conformation of existing CXCR4 homodimers and CXCR4-CD4 heterodimers [242]. This evidence concerns the gene CD4 and infection.