CCL3 and viral infectious disease: Moreover, our results also suggest that TLR3 siRNAtransfection significantly suppressed CCR5 expression inpolyI:C-stimulated THP1-Mφs and inhibited chemotaxistoward CCL3. TLR-3 is responsible for anti-viral immunityagainst several virus infections via double-strandedRNA recognition and the activation of multiple antiviralfactors in macrophages (20).