In the current article, we studiedthe effect of ATO and sorafenib on the expression patternof VEGFA (24), B-RAF, MEK1, MEK2, Beclin1, LC3-II,ULK1, RAF1, BCL-2 and PTEN in leukemic cell lines.We focused not only on apoptosis but also on autophagy.Previous studies demonstrated that angiogenesis factorssuch as VEGF-A play a vital role in cancer progressionand metastasis (25). Here, MAP2K2 is linked to cancer.