Consistently, it was reported that a high dose of SNP, a type of NO donor causes an anxiogenic‐like action in the elevated plus‐maze test.24 It has been demonstrated that 5‐HT1A receptor on the hippocampal DG granule cells is crucial for anxiety‐related behavior.33 Thus, excessive ONOO• eliminates the content of 5‐HT1A receptor in granule cells, which may finally induce anxiety phenotype. This evidence concerns the gene HTR1A and Anxiety.