Remarkably, nNOS activity inhibition in the DG blocked CORT‐induced anxiety behavior in the OFT (Figure 4G‐H, one‐way ANOVA, central distance: F2,29 = 4.47, P < .05; central time: F2,29 = 8.80, P < .01, n = 10‐11) without affecting the locomotors (Figure 4I). This evidence concerns the gene NOS1 and Anxiety.