We, thus, name this undesirable interaction between nNOS and 5‐HT1A receptor as “nNOS‐5‐HT1A receptor loop” (stress‐glucocorticoids‐nNOS‐Nitric oxides‐ONOO•‐5‐HT1A receptor ‐nNOS), which functions importantly in the pathology of stress‐associated anxiety behavior (Figure 5). The gene discussed is NOS1; the disease is Anxiety.