Downregulation of 5‐HT1A receptor in DG granule cells of the hippocampus is essential for induction of anxiety.33 By Western blot and RT‐PCR methods, we found that a high dose of CORT (20 mg/kg, s.c., 5 days) but not lower doses (10 and 5 mg/kg, s.c., 5 days) of CORT significantly reduced the protein and mRNA level of 5‐HT1A receptor in the DG of the hippocampus compared with vehicle‐treatment group (Figure 2A, one‐way ANOVA, Western blot: F3,8 = 10.36, P < .01, n = 3; RT‐PCR: F3,8 = 11.55, P < .01, n = 3). This evidence concerns the gene HTR1A and Anxiety.