Reportedly, stress is closely correlated with depression and anxiety.13 Chronic stress increases corticosterone (CORT, glucocorticoids in rodents), decreases 5‐HT1A receptor in the dentate gyrus (DG), and gives rise to anxiety‐related behaviors.14, 15 Hence, glucocorticoids may be the predominant substance that mediates the impact of stress on the hippocampus in the development of anxiety. The gene discussed is HTR1A; the disease is major depressive disorder.