NOS1 and Anxiety: Behavior measurement in the OPT showed that selective inhibition of nNOS located in the DG blocked the induction of anxiety behavior by CUMS (Figure 4 D‐E, one‐way ANOVA, central distance: F2,32 = 6.78, P < .01; central time: F2,32 = 7.74, P < .01, n = 11‐13).