Importantly, the miR‐302e‐induced tumor suppressive effect could be effectively reversed by circ‐CMPK1 or cyclin D1 overexpression both in vitro and in vivo, implying that the ceRNA regulatory network of circ‐CMPK1/miR‐302e/cyclin D1 is objectively present and plays an important role in NSCLC. Here, CMPK1 is linked to non-small cell lung carcinoma.