Alteration of this pathway is one of the best‐recognized abnormalities in endometrial cancer.10 It is suggested that low PTEN protein expression may be involved in pathogenesis and development of endometrial carcinoma.15 PTEN protein level can be altered upstream at the genetic level through mutation, but also at the transcriptional level or post‐translational level. This evidence concerns the gene PTEN and endometrial carcinoma.