Some studies showed that lack or low PTEN level is associated with worse prognosis,19, 20, 21 but the others suggest that loss of PTEN expression is associated with favourable prognosis.22, 23, 24 Gao et al24 found that the level of PTEN expression in patients with endometrial carcinoma was significantly related to differentiation (the expression of PTEN in high differentiated endometrial carcinoma was significantly higher than that in middle‐low differentiated one and clinical stage). The gene discussed is PTEN; the disease is endometrial carcinoma.