Transgenic expression of CHC22 in murine muscle caused similar accumulation of GLUT4 with CHC22, along with two other proteins involved in intracellular GLUT4 sorting, insulin-regulated aminopeptidase (IRAP) and VAMP2, and aged CHC22-transgenic animals developed hyperglycemia. This evidence concerns the gene CLTCL1 and Hyperglycemia.