There are evidences revealing that YAP can modulate tumour cell proliferation through regulating the expression of cell cycle proteins, such as p27Kip1, p2145 and cyclinD1.25, 28, 43 p27Kip1 is a cyclin‐dependent kinases inhibitor that involved in the pathogenesis of neuroblastoma. This evidence concerns the gene CDKN1B and neuroblastoma.