IGF2 and colorectal cancer: Actually, at present, there are no reports about how YAP regulates the expression of Akt at the transcription level; however, there are some articles reported the relationship between YAP and Akt.12, 47, 48, 49, 50, 51 For example, knock‐down of YAP can repress the activation of Akt in colorectal cancer cells,47 silencing of YAP expression markedly attenuates AMOT‐induced expression of p‐Akt,48 YAP induces IGF2‐mediated activation of Akt in medulloblastoma.12 These results suggest that Akt might be the downstream target of YAP.