CDKN1B and neuroblastoma: However, there are in vivo results suggesting that YAP, Akt and p27kip1 are related to neuroblastoma.13, 22, 66 YAP is significantly higher in the malignant neuroblastoma tissues of human, compared to the peritumoral tissues.13 Inhibition of the Akt signalling pathway shows therapeutic efficacy in neuroblastoma xenografts in vivo.66 Decrease of transcript levels of p27Kip1 increases human susceptibility to neuroblastoma.22