Several side effects and adverse events could be observed or detected in current study, including (i) hematological toxicities such as leukopenia, neutropenia, anemia, thrombocytopenia; (ii) AST/ALT elevation; (iii) hyperbilirubinemia; (iv) gastrointestinal toxicities such as anorexia, nausea, vomiting, diarrhoea; (v) fatigue; (vi) abdominal pain. Here, GPT is linked to anemia (phenotype).