The most common toxicities include: leukopenia occur in 36 cycles (50%) including grade 1/2 in 28 (38.9%) and grade 3/4 in 8 (11.1%), thrombocytopenia in 25 (36.1%) including grade 1/2 in 21 (29.2%) and grade 3/4 in 5 (6.9%), AST/ALT elevation in 8 (66.7%) including grade 1/2 in 36 (50.0%) and grade 3/4 in 12 (16.7%). This evidence concerns the gene GPT and Decreased total leukocyte count.