In agreement with it being a pivotal TSG, around half of human tumors harbor mutations in TP53. Interestingly, clear cell Renal Cell Carcinoma (ccRCC), the most common subtype of kidney cancer, seems to be an exception: only a small subset of tumors harbor mutations in TP53 (~3%)12. The gene discussed is TP53; the disease is nonpapillary renal cell carcinoma.