Since p53 is activated after DNA damage, we induced DNA damage in p53-null H1299 lung cancer cells co-transfected with PBRM1 and p53 followed by etoposide or bleomycin treatment and found PBRM1-p53 interactions were enhanced (lane 7 vs. lane 3 or lane 5 on Fig. 1b and lane 9 vs. lane 5 on Fig. 1c). The gene discussed is TP53; the disease is lung cancer.