Intrathecal administration of 5, 7-DHT significantly attenuated the increase of CXCL1 (Day 3 and 7: p < 0.001), and CXCL2 (Day 3: p < 0.001, day 7: p < 0.01) mRNA expression levels at both time points when compared to vehicle-treated mTBI mice (Fig. 4a). This evidence concerns the gene CXCL1 and concussion.