ALB and ischemia: However, the increased permeability of the BBB in our LPS and MRL/lpr models is more subtle than seen in some Alzheimer’s and hypoxia or ischemia models, where much larger molecules like albumin-conjugated Evan’s Blue dye (~66 kDa) and IgGs (~150 kDa) can permeate the BBB, and the coverage of vessels by pericytes can also be substantially decreased in these diseases45–47.