TGFB1 and metabolic dysfunction-associated steatohepatitis: A total of 396 genes were upregulated more than 2-fold (log2 fold change ≧ 1) in NASH-fib against HSCs, and GO analysis revealed that genes related to cell adhesion, extracellular matrix organization, cellular response to TGFβ, and wound healing were activated in NASH-fib compared to HSCs (Fig. 2b).