Using an optimized anti-SUPYN monoclonal antibody (clone: 3H6) (Supplementary Fig. S1) and a very rare tissue sample from a woman at 7 weeks of gestation who underwent elective hysterectomy for cervical cancer with her pregnancy in situ, we refined our understanding of SUPYN localization and confirmed prior descriptions of HLA-G, cytokeratin 7 (CK7) and known human placental fusogens and their partners in early gestation (Fig. 1). The gene discussed is ERVH48-1; the disease is cervical cancer.