Muc4−/− mice are resistant to experimental colitis and colitis-associated colorectal cancer29; Higher Muc4 expression in early-stage CAC patients was related to poorer survival30; Muc5AC is associated with inflammation while Muc 6 is related to the presence of neoplasia31; Muc20 gene expression was found significantly decreased in patients with active UC32. This evidence concerns the gene MUC4 and colitis.