Unexpectedly, neither knockdown nor knockout of RNF208 did change the expression of epithelial to mesenchymal transition (EMT) markers, such as E-cadherin and Vimentin, or the cell migration ability of both control and RNF208-deficient T47D cells (Supplementary Fig. 5), suggesting that loss of RNF208 may not be sufficient to induce aggressive phenotypes and cancer progression in luminal breast cancer subtypes. Here, CDH1 is linked to breast cancer.