VIM and cancer: Unexpectedly, neither knockdown nor knockout of RNF208 did change the expression of epithelial to mesenchymal transition (EMT) markers, such as E-cadherin and Vimentin, or the cell migration ability of both control and RNF208-deficient T47D cells (Supplementary Fig. 5), suggesting that loss of RNF208 may not be sufficient to induce aggressive phenotypes and cancer progression in luminal breast cancer subtypes.