Of note, half of these proteins (56%) were lower in HF cases, of which most (74%) were annotated as intracellular or membrane-bound proteins and were widely expressed (61% expressed in all HPA tissues) (Supplementary Fig. 1) although several were of likely vascular (P-selectin, tropomyosin-4) or skeletal muscle (fibroblast growth factor 6) origin. Here, TPM4 is linked to hydrops fetalis.