In contrast, 61% of the proteins that were higher in HF cases showed evidence of tissue enrichment and 68% were secreted proteins, including several well-known proteins with a highly plausible role in HF pathophysiology such as vascular endothelial growth factor A, angiogenin, endostatin, glucagon, erythropoietin, periostin. The gene discussed is COL18A1; the disease is hydrops fetalis.