The involvement of these muscle gene repositioning NETs, not only as novel causative alleles but also in mediating EDMD pathology caused by mutations in widely expressed nuclear envelope proteins, is further supported by WFS1, Tmem214, Tmem38A, and NET5/Samp1 being mislocalised in isolated differentiating EDMD muscle cells or muscle biopsy sections [33]. Here, TMEM38A is linked to Emery-Dreifuss muscular dystrophy.