SYNE2 and Emery-Dreifuss muscular dystrophy: Consistent with this variation, EDMD is also genetically variable: ~half of Emery–Dreifuss-like syndrome cases are linked to mutations in genes encoding 6 nuclear envelope proteins (emerin, lamin A, nesprin 1, nesprin 2, SUN1 and FHL1 [7], [8], [9], [10], [11]).