GSK3α negatively regulates STAT3 activity in atherosclerosis (McAlpine et al., 2015), whereas GSK3β indirectly promotes the phosphorylation of Y705 on STAT3 via membrane-associated tyrosine kinases (Beurel and Jope, 2008, Gao et al., 2017). This evidence concerns the gene GSK3A and atherosclerosis.