For example, we observe a 25% decrease in neurexin 2 and over 30% decrease in neurogranin abundance in AD APOE4 superior temporal gyrus compared to controls, whereas recently published biomarker studies observed increases in neurexin 2 and neurogranin in CSF of people with mild cognitive impairment or AD [14, 29, 41]. The gene discussed is NRGN; the disease is Cognitive impairment.