Similarly, the lncRNA KCNQ1OT1, which is involved in imprinting in Beckwith-Wiedemann syndrome by silencing lineage-specific transcription through chromatin regulation [28], is also enriched on histone H3 over input, as expected (Additional file 1: Figure S2A). Here, KCNQ1OT1 is linked to Beckwith-Wiedemann syndrome.