TGFB1 and congenital bilateral aplasia of vas deferens from CFTR mutation: Our recent analysis of miR profile in human AVICs demonstrates that AVICs from human aortic valves affected by CAVD have higher levels of miR-486 and lower levels of miR-204 and that pro-osteogenic factors, such as TGF-β1 and BMP-2, down-regulate miR-204 expression in AVICs from normal human aortic valves [32].