CASP3 and cancer: In terms of anti-cancer activity, anwuligan could induce apoptosis of human promyeloytic leukemia cells (HL-60) by activating caspase-3 [7], it also exhibits the anti-carcinogenic activity by strongly inhibiting the carcinogenic oral bacteria S. mutans [5] and ameliorating the side effects of cancer chemotherapy by regulating the activity of multidrug-resistant protein [8,9,10].