During CLD many peptide mediators, including platelet-derived growth factor (PDGF), monocyte chemoattractant protein-1 (MCP-1 or CCL2), angiotensin II (AT-II), vascular endothelial growth factor-A (VEGF-A) as well as ROS and/or hypoxic conditions, have been reported to stimulate HSC/MFs migration, then contributing to fibrosis progression [12,13,14,15,16,17]. Here, CCL2 is linked to congenital secretory chloride diarrhea 1.