OSM transcript levels were significantly increased also in specimens obtained from NASH patients as compared to those obtained from patients showing simple steatosis (no NASH, Figure 2A); moreover, OSM immunostaining was also significantly increased in sections from liver biopsies from NASH patients and in cells characterized by macrophage-like morphology (i.e., CD68 positive) (Figure 2B). This evidence concerns the gene CD68 and metabolic dysfunction-associated steatohepatitis.