FN1 and neoplasm: The fact that persistent senescent fibroblasts surrounding transformed tumor cells aggravate FN-enriched fibrosis [145] is substantiated by the findings that the fibroblast senescence induces myofibroblast differentiation in a paracrine manner to express a profibrotic SASP and eminent FN expression and that reduction of fibrillar FN formation ameliorates organ fibrosis [144,153,165].