For instance, FN matrix deposition, instead of provisional FN, has been deemed as one of markers in alternatively activated macrophages often designated as M2 macrophages within the pro-tumor inflammatory TMEs [197], whereas it has conversely been revealed that macrophages characteristic of the M1 type responsible for clearing damaged cells during the elimination stage of tumor transformation remain M1 type and are not converted to M2 type [198]. Here, FN1 is linked to neoplasm.