The possibility that FN overexpression accounts for normal epithelial senescence caused by various types of stresses [118,119,120,121,122,123] is substantially supported by the findings that silencing FN transcription or depleting periFN of pre-cancerous cells or pre-malignant tumor cells promotes characteristics of tumor progression, including proliferation, migration/invasion, tumor sizes, anchorage-independent cell growth, and angiogenesis [53,64,65,66,67,106,124,125,126,127]. The gene discussed is FN1; the disease is neoplasm.