FN1 and neoplasm: These findings also confirm that the FN expression and periFN pertinent to E–M phenotypes are required for FNhigh CTC colonization but render tumor dormancy in distant organs and M–E phenotypes drives FNhigh DTCs outgrowth from dormancy and set forth an intriguing possibility that functionalities of individual molecules involved in E–M and M–E plasticity and phenotypical changes between epithelial and mesenchymal morphologies can be uncoupled.