Consistently, a DPP IV-derived polypeptide harboring the FN-binding site specifically blocks A1AT-promoted lung colonization of CL1-5 with a high level of periFN assembly, confirming that the specific adhesion between periFN on CTCs and DPP IV on lung endothelia readily promotes tumor metastasis in the lungs [2]. This evidence concerns the gene FN1 and neoplasm.