The HSP90 deficiency-induced senescence may be evaded if endogenous FN synthesis is prohibited, rationalizing why, in order to allow transformed tumor cells to continue proliferating, they must downregulate their endogenous FN synthesis to foster the regrowth of senescent cells to become transformed tumor cells when the genome instability reaches the degree to which cellular senescence can be evaded and the regrown senescent cells become tumorigenic [20,107,135,136]. The gene discussed is FN1; the disease is neoplasm.