ANGPTL4 and neoplasm: CTC-secreted angiopoietin-like 4 (ANGPTL4) or its C-terminal fragment are competent in antagonizing vascular endothelial cell-cell junctions to facilitate extravasation and metastasis of tumor cells due to direct interaction with adhesion molecules, e.g., a FN receptor α5β1, involved in cell junctions [303,304].