Additionally, macrophages have been reported to be capable of remodeling FN-containing ECM matrix deposition and driving pro-malignant interactions between tumor cells and ECM in the TMEs [181,182] Clinically, more than 80% of all meta-analytic results demonstrate a strong association between the presence of macrophage and patients’ poor prognosis in various types of cancer [183,184]. The gene discussed is FN1; the disease is cancer.