When deposited into extracellular matrices (ECMs) in the immunosuppressive tumor microenvironments (TMEs) in which tumor cells are often the driving force to induce inflammatory responses, FN promotes early tumor progression [10,11,12,13,14,15] but is paradoxically correlated with a better prognosis [7,16,17,18,19] (Figure 1B,C). Here, FN1 is linked to neoplasm.