FN1 and neoplasm: While fibroblasts are thought to be temporarily senescent to control fibrogenesis in the neighbor stroma and recruit pro-inflammatory cells to clear the damaged senescent cells, the transient fibrolytic senescent fibroblasts are altered to be persistent FN-generating fibrogenic fibroblasts in response to the altered secretome of tumor cells that evolve to escape immunosurveillance during tumor transformation [107,145,164].