FN1 and neoplasm: As low FN expressing (FNlow) tumor cells that bypass senescence effects at the elimination stage and drive persistent FN deposition in the ECM within TMEs to facilitate tumor growth and progression prosperously proliferate and enlarge tumor sizes up to ~100–200 μm away from blood vessels, the low oxygen pressure within the TMEs renders hypoxia due to insufficient blood vessel supply [199,200,201,202].