Along with the anti-inflammatory effects of VIP in RA-SF through its action on TLR, this neuropeptide has been described to decrease the pro-inflammatory peptides corticotropin releasing factor (CRF) and urocortin (UCN)-1, while increasing the expression of the potential anti-inflammatory agents UCN-3 and CRF receptor 2 (CRFR2). This evidence concerns the gene UCN and rheumatoid arthritis.