IFI16 and head and neck squamous cell carcinoma: By the means of in vitro studies, it was observed that ectopic expression of IFI16 in an IFI16-null HNSCC-derived cell line (HNO136) suppressed both proliferation and transforming activity of these cells in vitro, indicating that IFI16 exerts a potent antiproliferative effect in HNSCC [9].