Once in the tumor tissue, these cells begin to synthesize immunosuppressive cytokines, actions that lead to an increase in the concentration of myeloid-derived suppressor cells (MDSCs), activation of Fox3+ regulatory T-lymphocytes (Tregs), polarization of tumor-associated macrophages (TAMs) in the M2 phenotype, and suppression of T proliferation cells [3]. This evidence concerns the gene RBFOX3 and neoplasm.