Tumors treated with control gel were infiltrated with large colonies of arginase-1-positive macrophages, each colony contained approximately 50 to 200 cells, whereas the treatment with Hsp70-containing gel led to a significant decrease in arginase-1-positive macrophages in the tumor locus, and they were represented by single cells that did not form colonies, suggesting that the reduction of eHsp70 in the TME leads to enhanced recruitment of M2-type macrophages (Figure 7). Here, HSPA1A is linked to neoplasm.