EGFR and cancer: Despite the reports of numerous intrinsic factors, such as mutations of EGFR and KRAS, in cancer cells contributing to the transition from noninvasive to invasive lesions [51,52], inflammatory cells and cytokines in the lung microenvironment also play a crucial role in the malignant progression [53,54], and which also influence the expression or activity of glycotransferase [55,56].